Targeting redox altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder ScienceDirect Dihexa shows neurotrophic activity exceeding BDNF in preclinical studies Alpha BioMed posted on the topic LinkedIn Ip Lab Synaptic Plasticity & Memory Formation Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted AngIV Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP PS1 Mouse via the PI3K AKT Signaling Pathway