A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite
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napqi and glutathione Mechanisms of Hepatocyte Detoxification