Cysteine conjugates of acetaminophen and p aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK 2 cells Archives of Toxicology Springer Nature Link Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Tylenol is just poison. , Dr. Stanton Hom explains how a simple over the counter drug can deplete glutathione, dysregulate detox, and show up in the literature as a risk factor for autism, asthma, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Figure 1: CMAJ